A new, simple and sensitive spectrometric method in ultraviolet region has been developed for determination of desonide in bulk and pharmaceutical formulations. Desonide exhibit absorption maxima at 247nm with apparent molar Absorptivity 4.2000×104L/mol.cm in methanol .beer’s law was found to be obeyed in concentration range of 2-22 ug/mL The method is accurate, simple, precise, reproducible, requiring no prior separation and economical procedures for Estimation of desonide in topical cream formulation. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically and recovery studies.
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